”En stark och tydlig koppling till forskarsamhället är oerhört viktig för vår nuvarande och kommande utveckling. Lipigon vilar stadigt på Olivecronas över 50-åriga forskningsgärning men vi får inte bli bekväma och tappa den spets vi har.”

Stefan K Nilsson

VD/Grundare Lipigon

Lipigons huvudgrundare professor emerita Gunilla Olivecrona och Dr. Stefan K. Nilsson är aktiva lipidforskare. Nedan visas utvalda publikationer inom Lipigons forskningsfält från 2006 och framåt.

Orginalpublikationer

“Drug-target Mendelian randomization analysis supports lowering plasma ANGPTL3, ANGPTL4, and APOC3 levels as strategies for reducing cardiovascular disease risk”. Landfors, F., Henneman, P., Chorell, E., Nilsson, S.K., Kersten, S. European Heart Journal Open, Volume 4, Issue 3, May 2024, oeae035, doi: 10.1093/ehjopen/oeae035

“Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation". Fischer, A.W., Jaeckstein, M.Y., Gottschling, K., Heine, M., Sass, F., Mangels, N., Schlein, C., Worthmann, A., Bruns, O.T., Yuan, Y., Zhu, H., Chen, O., Ittrich, H., Nilsson, S.K., Stefanicka, P., Ukropec, J., Balaz, M., Dong, H., Sun, W., Reimer, R., Scheja, L., Heeren, Cell Metabolism, online Dec 22, 2020, doi: 10.1016/j.cmet.2020.12.001

“On the mechanism of angiopoietin-like protein 8 for control of lipoprotein lipase activity”. Kovrov, O., Kristensen, K.K., Larsson, E., Ploug, M., Olivecrona, G.. Journal of Lipid Research. 60:783–793, April 2019, doi: 10.1194/jlr.M088807

“Lipoprotein lipase in mouse kidney: effects of nutritional status and high-fat diet”. Nyrén, R., Makoveichuk, E., Malla, S., Kersten, S., Nilsson, S.K., Ericsson, M., Olivecrona, G. American Journal of Physiology-Renal Physiology. 316:F558-F571, Jan 2019, doi: 10.1152/ajprenal.00474.2018.

“TNF-α decreases lipoprotein lipase activity in 3T3-L1 adipocytes by up-regulation of angiopoietin-like protein 4”. Makoveichuk, E., Vorrsjö, E., Olivecrona, T., Olivecrona, G. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1862:533-540, 2017, doi: 10.1016/j.bbalip.2017.02.005

“Lipoprotein lipase activity and interactions studied in human plasma by isothermal titration calorimetry”. Reimund, M., Kovrov, O., Olivecrona, G., Lookene, A. Journal of Lipid Research. 58:279-288, 2017, doi: 10.1194/jlr.D071787.

“Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport”. Bartelt, A., John, C., Schaltenberg, N., Berbée, J.F.P., Worthmann, A., Cherradi, M.L., Schlein, C., Piepenburg, J., Boon, M.R., Rinninger, F., Heine, M., Toedter, K., Niemeier, A., Nilsson, S.K., Fischer, M., Wijers, S.L., van Marken Lichtenbeldt, W., Scheja, L., Rensen, P.C.N., Heeren, Nature Communications. 8:15010, 2017, doi:10.1038/ncomms15010.

“A low-carbohydrate high-fat diet decreases lean mass and impairs cardiac function in pair-fed female C57BL/6J mice”. Nilsson, J., Ericsson, M., Motamedi Joibari, M., Anderson, F., Carlsson, L., Nilsson, S.K., Sjödin, A., Burén, Nutrition & Metabolism. 13:79, 2016, doi: 10.1186/s12986-016-0132-8.

“ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoproteins lipase and that unfolding is counteracted by GPIHBP1”. Mysling, S., Kristensen, K.K., Larsson, M., Kovrov, O., Bensadoun, A., Jørgensen, T.D.J., Olivecrona, G., Young S.G., Ploug, M.. eLIFE 5:e20958, 2016.

“Structure-activity relationships of small molecules lowering plasma triglycerides”. Caraballo, R., Larsson, M., Nilsson, S.K., Ericsson, M., Qian, W., Nguyen Tran, N.P., Kindahl, T., Svensson, R., Saar, V., Artursson, P., Olivecrona, G., Enquist, P.-A., Elofsson, M. The European Journal of Medicinal Chemistry, 103:191-209, 2015, doi: DOI: 10.1016/j.ejmech.2015.08.058.

“The tissue distribution of lipoprotein lipase determines where chylomicrons bind”. Savonen, R., Hiden, M. Hultin, M., Zechner, R., Levak-Frank, S., Olivecrona, G., Olivecrona, T.  Journal of Lipid Research, 56:588-598, 2015, 10.1194/jlr.M056028

”Apolipoprotein CIII links insulin resistance to b-cell failure in diabetes”.  Åvall, K., Alli, Y., Leibiger, I.B., Leibiger, B., Moede, T., Paschen, M., Dicker, A., Daré, E., Köhler, M., Ilegems, E., Abdulreda, M.H., Graham, M., Crooke, R.M., Tay, V.S.Y., Refai, E., Nilsson, S.K., Jacob, S., Selander, L., Berggren, P.-O., Juntti-Berggren, L. The Proceedings of the National Academy of Sciences (PNAS), USA, 112:E2611-E2619, 2015, doi: 10.1073/pnas.1423849112.

“Identification of a small molecule that stabilizes lipoprotein lipase in vitro and lowers triglycerides in vivo”. Caraballo, R., Ericsson, M., Lookene, A., Enquist, P.-A., Elofsson, M., Nilsson, S.K., Olivecrona, G. Biochemical and Biophysical Research Communications, 450:1063-1069, 2014, doi:10.1016/j.bbrc.2014.06.114.

“Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise”, Catoire, M., Alex, S., Paraskevopulos, N., Mattijssen, F., Evers-van Gogh, I., Schaart, G., Jeppesen, J., Kneppers, A., Mensink, M., Voshol, P.J., Olivecrona, G., Soon Tan, N., Hesselink, M.K.C., Berbée, J.F., Rensen, P.C.N., Kalkhoven, E., Schrauwen, P., Kersten, S.. The Proceedings of the National Academy of Sciences, USA, 111:E1043-1052, 2014, doi: 10.1073/pnas.1400889111.

“Structural and functional analysis of APOA5 mutations identified in patients with severe hypertriglyceridemia”. Mendoza-Barbera, E., Julve, J., Nilsson, S.K., Lookene, A., Martín-Campos, J.M., Roig, R., Lechuga-Sancho, A.M., Sloan, J.H., Fuentes-Prior, P., Blanco-Vaca, F.  Journal of Lipid Research, 54:649-661, 2013, doi: 10.1016/j.bbrc.2014.06.114.

“Apolipoprotein C-I and C-III inhibit lipoprotein lipase activity by displacement of the enzyme from lipid droplets”. Larsson, M., Vorrsjo, E., Talmud, P., Lookene, A., Olivecrona G.. Journal of Biological Chemistry, 288:33997-40008, 2013, doi: 10.1074/jbc.M113.495366.

“Depletion of Foxp3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis”. Klingenberg, R., Gerdes, N., Badeau,R.M. Giestra, A., Strodthoff , D., Ketelhuth, D.F., Lundberg, A.M., Rudling, M.,  Nilsson, S.K., Olivecrona, G.,  Zoller, S., Lohmann, C., Lüscher, T.F., Jauhiainen, M., Sparwasser T., Hansson, G.K.  Journal of Clinical Investigation. 123:1223-1334, 2013, doi: 10.1172/JCI63891.

“Localization of lipoprotein lipase and GPHBP1 in mouse pancreas: effects of diet and leptin deficiency“. Nyrén, R., Chang, C.L., Lindström, P., Barmina, A., Vorrsjö, E., Ali, Y., Juntti-Berggren, L., Bensadoun, A., Young, S.G., Olivecrona, T., Olivecrona, G.. BMC Physiology. 12:14, 2012, doi: 10.1186/1472-6793-12-14.

“Linking nutritional regulation of ANGPTL4, GPIHBP1, and LMF1 to lipoprotein lipase activity in rodent adipose tissue”. Kroupa, O., Vorrsjö, E., Stienstra, R., Mattijssen, F., Nilsson, S.K., Sukonina, V., Kersten, S., Olivecrona, G., Olivecrona, T. BMC Physiology. 12:13, 2012, doi: 10.1186/1472-6793-12-13.

“Triacylglycerol-rich lipoproteins protect lipoprotein lipase from inactivation by ANGPTL3 and ANGPTL4”. Nilsson, S.K., Anderson, F., Ericsson, M., Larsson, M., Makoveichuk, E., Lookene, A., Heeren, J., Olivecrona, G.. Biochim Biophys Acta. 1821:1370-1378, 2012, doi:10.1016/j.bbalip.2012.06.003.

“Impaired LDL receptor-related protein 1 translocation correlates with improved dyslipidemia and atherosclerosis in apoE-deficient mice”. Gordts, P.L.S., Bartelt, A., Nilsson, S.K., Annaert, W., Christoffersen, C., Nielsen, L.B., Heeren, J., Roebroek, A.J.M. PLos One 7:e38330, 2012, doi: 10.1371/journal.pone.0038330.

“Intermittent hypoxia inhibits clearance of triglyceride rich lipoproteins and inactivates adipose lipoprotein lipase in a mouse model of sleep apnea”.  Drager, L.F., Li, J., Shin, M.-K. Reinke, C., Aggrawal, N.R., Jun, J.C., Bevans-Fonti, S.,  Sztalryd, C., O’Byrne, S.M., Kroupa, O., Olivecrona, G., Blaner W.S., Polotsky, V.Y., Europan Heart Journal, 33:783-790, 2012, doi: 10.1093/eurheartj/ehr097.

“GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries.” Davies, B.S.J., Beigneux, A.P., Barnes, R.H., Tu, Y., Gin, P., Weinstein, M.M., Nobumori, C., Nyrén, R., Goldberg, I., Olivecrona, G., Bensadoun, A., Young, S.G., Fong, L.G. Cell Metabolism, 12:42-52, 2010, doi: 10.1016/j.cmet.2010.04.016.

“Site-directed mutagenesis of apolipoprotein CII to probe the role of the secondary structure for activation of lipoprotein lipase.” Shen, Y., Lookene, A., Zhang, L., Olivecrona, G., Journal of Biological Chemistry, 285:7484-7492, 2010, doi: 10.1074/jbc.M109.022046.

“Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia”. Olivecrona, G., Ehrenborg, E., Semb, H., Makoveichuk, E., Lindberg, A., Hayden, M.R., Gin, P., Davies, B.S.J., Weinstein, M.M., Fong, L.G., Beigneux, A.P., Young, S.G., Olivecrona, T., and Hernell, O, Journal of Lipid Research 1535-1545, 2010, doi: 10.1194/jlr.M002717.

“Endocytosis of apolipoprotein AV by members of the low density lipoprotein receptor and the Vps10p domain receptor families”. Nilsson, S.K., Christensen, S., Raarup, M.K., Ryan, R.O., Nielsen, M.S., Olivecrona G. Journal of Biological Chemistry, 283:25920-25927, 2008, doi: 10.1074/jbc.m802721200.

“Effects of Six APOA5 Variants, Identified in Patients With Severe Hypertriglyceridemia, on In Vitro Lipoprotein Lipase Activity and Receptor Binding“. Dorfmeister, B., Zeng, W.W., Dichlberger, A., Nilsson, S.K., Schaap, F.G., Hubacek, J.Lookene, A., Putt, W., Whittall, R., Lee, P.J., Lins. L., Delsaux, N., Nierman, M., Kuivenhoven, J.A., Kastelein, J.J., Vrablik, M., Olivecrona, G., Schneider, W.J., Heeren, J., Humphries, S.E., Talmud, P.J. Arteriosclerosis, Thrombosis, Vascular Biology 28:1866-1871, 2008, doi: 10.1161/ATVBAHA.108.172866.

“Apolipoprotein A-V interaction with members of the low density lipoprotein receptor gene family”. Nilsson, S.K., Lookene, A., Beckstead, J.A., Gliemann, J., Ryan, R.O., Olivecrona, G. Biochemistry 46:3896-3904, 2007, doi: 10.1021/bi7000533.

“Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue”. Sukonina, V., Looekene, A., Olivecrona, T., Olivecrona, G. PNAS USA In press, 2006, doi: 10.1073/pnas.0604026103.

Bokkapitel och reviews

“Role of lipoprotein lipase in lipid metabolism”. Olivecrona, G. Current Opinion in Lipidology, 27:233-241, 2016, doi: 10.1097/MOL.0000000000000297.

“Apolipoprotein A-V; a potent triglyceride reducer”.  Nilsson, S.K., Heeren, J., Olivecrona G., Merkel, M. Atherosclerosis. 219:15-21, 2011, doi: 10.1016/j.atherosclerosis.2011.07.019.